Chemotherapeutic Engineering | Collected Papers of Si-Shen Feng-A Trib

Book

Chemotherapeutic Engineering

ABSTRACT

This book is a collection of the major publications of the authors in the emerging area of chemotherapeutic engineering. It describes and demonstrates the concept, feasibility, safety and prospect of chemotherapeutic engineering through a full spectrum of proof-of-concept experiments from design, characterization, in vitro cellular uptake, cytotoxi

TABLE OF CONTENTS

part |2 pages

Part I - Introduction

chapter 1|16 pages

Chemotherapeutic Engineering: Concept, Feasibility, Safety and Prospect—A Tribute to Shu Chien’s on His 82nd Birthday

part |2 pages

Part II - Chemotherapeutic Engineering: Concepts

chapter 2|60 pages

- Chemotherapeutic Engineering: Application and Further Development of Chemical Engineering Principles for Chemotherapy of Cancer and Other Diseases

chapter 3|24 pages

- New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where Are We Now?

chapter 4|24 pages

- Nanoparticles of Biodegradable Polymers for New-Concept Chemotherapy

chapter 5|8 pages

- Nanoparticles of Biodegradable Polymers for Cancer Treatment

part |2 pages

Part III - Chemotherapeutic Engineering: Feasibility

chapter 6|16 pages

- Chemotherapeutic Engineering: Vitamin E TPGS-Emulsified Nanoparticles of Biodegradable Polymers Realized Sustainable Paclitaxel Chemotherapy for 168 h in vivo

part |2 pages

Part IV - Chemotherapeutic Engineering: Further Proof-of Concept Experimental Results

chapter 7|22 pages

- In vitro and in vivo Investigation on PLA–TPGS Nanoparticles for Controlled and Sustained Small Molecule Chemotherapy

chapter 8|16 pages

In vitro and in vivo Evaluation of Methoxy Polyethylene Glycol–Polylactide Nanoparticles for Small-Molecule Drug Chemotherapy

chapter 9|20 pages

- The Drug Encapsulation Efficiency, in vitro Drug Release, Cellular Uptake and Cytotoxicity of Paclitaxel-Loaded Poly(Lactide)–Tocopheryl Polyethylene Glycol Succinate Nanoparticles

chapter 10|16 pages

- Nanoparticles of Poly(D,L-Lactide)/Methoxy Poly(Ethylene Glycol)-Poly(D,L-Lactide) Blends for Controlled Release of Paclitaxel

chapter 11|14 pages

In vitro and in vivo Studies on Vitamin E TPGS-Emulsified Poly(D,L-Lactic-co-Glycolic Acid) Nanoparticles for Paclitaxel Formulation

chapter 12|18 pages

- Nanoparticles of Poly(Lactide)/Vitamin E TPGS Copolymer for Cancer Chemotherapy: Synthesis, Formulation, Characterization and in vitro Drug Release

chapter 13|22 pages

A Novel Controlled Release Formulation for the Anticancer Drug Paclitaxel (Taxol R© ): PLGA Nanoparticles Containing Vitamin E TPGS

chapter 14|22 pages

Fabrication, Characterization and in vitro Release of Paclitaxel (Taxol R© Loaded Poly(Lactic-co-Glycolic Acid) Microspheres Prepared by Spray Drying Technique with Lipid/Cholesterol Emulsifiers

chapter 15|30 pages

Effects of Emulsifiers on the Controlled Release of Paclitaxel (Taxol R© from Nanospheres of Biodegradable Polymers

part |2 pages

Part V - Chemotherapeutic Engineering: Drug Targeting

chapter 16|8 pages

- Copolymer Technology for Advanced Nanomedicine

chapter 17|28 pages

- A Strategy for Precision Engineering of Nanoparticles of Biodegradable Copolymers for Quantitative Control of Targeted Drug Delivery

chapter 18|20 pages

- Folic Acid Conjugated Nanoparticles of Mixed Lipid Monolayer Shell and Biodegradable Polymer Core for Targeted Delivery of Docetaxel

chapter 19|24 pages

- Quantitative Control of Targeting Effect of Anticancer Drugs Formulated by Ligand-Conjugated Nanoparticles of Biodegradable Copolymer Blend

chapter 20|28 pages

- Trastuzumab-Functionalized Nanoparticles of Biodegradable Copolymers for Targeted Delivery of Docetaxel

chapter 21|20 pages

- Folate-Decorated Poly(Lactide-co-Glycolide)-Vitamin E TPGS Nanoparticles for Targeted Drug Delivery

chapter 22|8 pages

- Ligand-Conjugated Nanoparticles of Biodegradable Polymers for Targeted Delivery of Imaging and Therapeutic agents to Biological Cells

chapter 23|22 pages

Formulation of Docetaxel by Folic Acid-Conjugated D-α-Tocopheryl Polyethylene Glycol Succinate 2000 (Vitamin E TPGS2k)Micelles for Targeted and Synergistic Chemotherapy

chapter 24|22 pages

Targeted Delivery of Paclitaxel Using Folate-Decorated Poly(Lactide)—Vitamin E TPGS Nanoparticles

part |2 pages

Part VI - Chemotherapeutic Engineering: Multifunctional Nanoparticles

chapter 25|26 pages

- Multifunctional Nanoparticles of Biodegradable Copolymer Blend for Cancer Diagnosis and Treatment

chapter 26|20 pages

- Targeting and Imaging Cancer Cells by Folate-Decorated, Quantum Dots–Loaded Nanoparticles of Biodegradable Polymers

chapter 27|26 pages

- Multifunctional Poly(D,L-Lactide-co-Glycolide)/Montmorillonite (PLGA/MMT) Nanoparticles Decorated by Trastuzumab for Targeted Chemotherapy of Breast Cancer

part |2 pages

Part VII - Chemotherapeutic Engineering: Prodrugs

chapter 28|28 pages

- Doxorubicin Conjugated to D-α-Tocopheryl Polyethylene Glycol Succinate and Folic Acid as a Prodrug for Targeted Chemotherapy

chapter 29|24 pages

- Doxorubicin Conjugated to D-α-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS): Conjugation Chemistry, Characterization, in vitro and in vivo Evaluation

part |2 pages

Part VIII - Chemotherapeutic Engineering: Oral Chemotherapy

chapter 30|6 pages

- Nanothermotherapy by High Performance Magnetic Nanoparticles

chapter 31|26 pages

- Poly(Lactide)-Vitamin E Derivative/Montmorillonite Nanoparticle Formulations for the Oral Delivery of Docetaxel

chapter 32|18 pages

- Enhanced Oral Bioavailability of Paclitaxel Formulated in Vitamin E-TPGS Emulsified Nanoparticles of Biodegradable Polymers: in vitro and in vivo Studies

chapter 33|16 pages

- Self-Assembled Nanoparticles of Poly(Lactide)-Vitamin E TPGS Copolymers for Oral Chemotherapy

chapter 34|20 pages

- Effects of Particle Size and Surface Coating on Cellular Uptake of Polymeric Nanoparticles for Oral Delivery of Anticancer Drugs

chapter 35|18 pages

Poly(D,L-Lactide-co-Glycolide)/ Montmorillonite Nanoparticles for Oral Delivery of Anticancer Drugs

part |2 pages

Part IX - Chemotherapeutic Engineering: Drug Delivery across the Blood–Brain Barrier

chapter 36|30 pages

- Effects of Surface Modification on Delivery Efficiency of Biodegradable Nanoparticles across the Blood–Brain Barrier

chapter 37|24 pages

- Transferrin-Conjugated Nanoparticles of Poly(Lactide)-D-α-Tocopheryl Polyethylene Glycol Succinate Diblock Copolymer for Targeted Drug Delivery across the Blood–Brain Barrier

part |2 pages

Part X - Chemotherapeutic Engineering: Multimodal Imaging

chapter 38|8 pages

- Nanotechnology for Multimodal Imaging

chapter 39|22 pages

Multimodal Tumor Imaging by Iron Oxides and QDs Formulated in PLA-TPGS Nanoparticles

chapter 40|22 pages

Vitamin E (D-Alpha-Tocopheryl-co-Poly(Ethylene Glycol) 1000 Succinate) Micelles-Superparamagnetic Iron Oxide Nanoparticles for Enhanced Thermotherapy and MRI

chapter 41|24 pages

Superparamagnetic Iron Oxide—Loaded Poly(Lactic Acid)-D-α- Tocopherol Polyethylene Glycol 1000 Succinate Copolymer Nanoparticles as MRI Contrast Agent

chapter 42|24 pages

- Formulation, Characterization, and in vitro Evaluation of Quantum Dots Loaded in Poly(Lactide)-Vitamin E TPGS Nanoparticles for Cellular and Molecular Imaging

chapter 43|26 pages

- Formulation of Superparamagnetic Iron Oxides by Nanoparticles of Biodegradable Polymers for Magnetic Resonance Imaging

part |2 pages

Part XI - Molecular biomaterials for Nanomedicine

chapter 44|44 pages

- Vitamin E TPGS as a Molecular Biomaterial for Drug Delivery