ABSTRACT

The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to their application in clinical practice. New imaging and therapeutic approaches need to be tested and validated first in animals before application to humans.

Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. Useful to established researchers as well as newcomers to the field, this handbook shows readers how to exploit and integrate these imaging and treatment modalities and techniques into their own research.

The book first presents introductory material on small animal imaging, therapy, and research ethics. It next covers ionizing radiation and nonionizing radiation methods in small animal imaging, hybrid imaging, and imaging agents. The book then addresses therapeutic research platforms and image quantification, explaining how to ensure accurate measurements of high-quality data. It concludes with an overview of many small animal imaging and therapy applications that demonstrate the strength of the techniques in biomedical fields.

section I|47 pages

Introduction to Small Animal Imaging, Therapy, and Applications

section II|69 pages

Small Animal Imaging Ionizing Radiation

section III|45 pages

Small Animal Imaging Nonionizing Radiation

chapter 9|19 pages

MR Imaging

chapter 10|23 pages

Optical Imaging

section IV|81 pages

Hybrid Imaging

section VIII|137 pages

Applications

chapter 25|10 pages

Small Animal Imaging and Therapy

How They Affect Patient Care

chapter 27|22 pages

Imaging of Intracellular Targets

chapter 30|19 pages

Imaging Angiogenesis

chapter 32|9 pages

Vessel Wall Imaging