ABSTRACT

Human cells produce at least 30,000 different proteins. Each has a specific function characterized by a unique sequence and native conformation that allows it to perform that function. While research in this post-genomic era has created a deluge of invaluable information, the field has lacked for an authoritative introductory text needed to inform

chapter |2 pages

Introduction to Part I

chapter |2 pages

From Building Blocks to 3-D Structure

chapter 1|16 pages

Amino Acids

chapter 2|14 pages

Noncovalent Interactions

chapter 3|24 pages

Structural Organization of Proteins

chapter 4|20 pages

The Biosynthesis of Proteins

chapter 5|18 pages

Posttranslational Modifications

chapter |2 pages

Folding of Proteins

chapter 6|22 pages

Protein Folding

chapter 7|12 pages

Intracellular Sorting of Proteins

chapter |2 pages

Protein Degradation

chapter 8|8 pages

Protein Turnover

chapter |2 pages

Introduction to Part II

chapter 10|8 pages

Crystallography and X-Ray Diffraction

chapter 11|10 pages

Optical Spectroscopy

chapter 12|12 pages

Nuclear Magnetic Resonance (NMR)

chapter 13|6 pages

Methods to Follow Protein Folding

chapter 14|4 pages

Mass Spectrometry

chapter 15|14 pages

Chemical Synthesis of Peptides and Proteins

chapter |2 pages

Introduction to Part III

chapter 16|14 pages

Protein Engineering and Gene Silencing

chapter 17|16 pages

Protein–Ligand Interactions

chapter 18|12 pages

Sequence Analysis and Function Prediction

chapter 19|6 pages

Protein Structure Prediction

chapter 20|18 pages

Proteomics

chapter |2 pages

Introduction to Part IV

chapter 21|30 pages

Enzymes

chapter 22|10 pages

Nucleic Acid– Binding Proteins

chapter 23|14 pages

Cell Surface Receptors and Signaling

chapter 24|6 pages

Membrane Proteins

chapter 25|12 pages

Antibodies

chapter 26|10 pages

Fibrous Proteins

chapter 27|14 pages

Selected Classes of Bioactive Peptides

chapter |2 pages

Introduction to Part V

chapter 28|8 pages

Misfolding-Based Diseases

chapter 29|6 pages

Miscleavage-Based Diseases

chapter 30|6 pages

Missequence-Based Diseases

chapter 31|14 pages

Peptides and Proteins as Drugs