ABSTRACT

This handbook presents the most recent technological advances and applications in the areas of biomedical photonics. This second edition contains introductory material and covers the state-of-the-art methods and instrumentation for biomedical photonic technologies. It integrates interdisciplinary research and development critically needed for scientists, engineers, manufacturers, teachers, students, and clinical providers to learn about the most recent advances and predicted trends in instrumentation and methods as well as clinical applications in important areas of biomedical photonics. Extensive references are provided to enhance further study.

Volume One: Photonics and Tissue Optics. Optical Properties of Tissues. Light-Tissue Interactions. Theoretical Models and Algorithms in Optical Diffusion Tomography. Basic Instrumentation. Basic Instrumentation in Photonics. Optical Fibers and Waveguides for Medical Applications. Fiberoptics Probe Design. Laser and Optical Radiation Safety in Biophotonics. Photonic Detection and Imaging Techniques. Biological Imaging Spectroscopy. Lifetime-Based Imaging. Confocal Microscopy. Two-Photon Excitation Fluorescence Microscopy. Laser Doppler Perfusion Monitoring and Imaging. Light Scatter Spectroscopy and Imaging of Cellular and Subcellular Events. Tissue Viability Imaging. Photothermal Detection and Tracking of Individual Non-fluorescent Nanosystems. Thermal Imaging. Multidimensional fluorescence imaging of biological tissue. Speckle Correlometry. Spectroscopic Data in Biological and Biomedical AnalysisVolume Two: Biomedical Analysis, Sensing and Imaging. Biosensors for Medical Applications. Glucose Monitoring. Biochips and MicroArrays: Tools for the New Medicine. Atomic Spectroscopy for Biological and Clinical Analysis. Flow Cytometry. Capillary Electrophoresis Techniques in Biomedical Analysis. Surface Plasmon Resonance Imaging: Principle, Development, and Biomedical Applications. Surface-Enhanced Raman Scattering (SERS) for Biomedical Diagnostics. Functional Imaging with Diffusing Light. Molecular Contrast Optical Coherence Tomography. Multiscale Photoacoustic Microscopy and Macroscopy. Polarized light for Medical Diagnostics. Optical Pumping and MRI of Hyperpolarized Spins. Biomedical Diagnostics and Optical Biopsy. Fluorescence Spectroscopy for Biomedical Diagnostics. Elastic-Scattering Spectroscopy and Diffuse Reflectance. Quantitative Diffuse Reflectance Imaging of Tumor Margins. Near Infrared Fluorescence Imaging and Spectroscopy in Random Media and Tissues. Interferometric light scattering techniques for measurin