ABSTRACT

The unprecedented amount of data produced with high-throughput experimentation forces biologists to employ mathematical representation and computation to glean meaningful information in systems-level biology. Applying this approach to the underlying molecular mechanisms of tumorgenesis, cancer research is enjoying a series of new discoveries and biological insights. Unique in its dualistic approach, this book introduces the concepts and theories of systems biology and their applications in cancer research. It presents basic cancer biology and cutting-edge topics of cancer research for computational biologists alongside systems biology analysis tools for experimental biologists.

part I|212 pages

Cancer Systems Biology: Concepts and Applications

chapter Chapter 1|20 pages

A Roadmap of Cancer Systems Biology

chapter Chapter 11|22 pages

Cancer Gene Prediction Using a Network Approach

part II|90 pages

Cancer Biology: Basic Concepts and Cutting-Edge Topics

chapter Chapter 13|28 pages

Epithelial-to-Mesenchymal Transition (EMT)

The Good, the Bad, and the Ugly

chapter Chapter 14|21 pages

Tumors and Their Microenvironments

chapter Chapter 15|20 pages

Tumor Angiogenesis

Cell-Microenvironment Interactions

part III|92 pages

Data Resources and Software Tools for Cancer Systems Biology