ABSTRACT
The unprecedented amount of data produced with high-throughput experimentation forces biologists to employ mathematical representation and computation to glean meaningful information in systems-level biology. Applying this approach to the underlying molecular mechanisms of tumorgenesis, cancer research is enjoying a series of new discoveries and biological insights. Unique in its dualistic approach, this book introduces the concepts and theories of systems biology and their applications in cancer research. It presents basic cancer biology and cutting-edge topics of cancer research for computational biologists alongside systems biology analysis tools for experimental biologists.
TABLE OF CONTENTS
part I|212 pages
Cancer Systems Biology: Concepts and Applications
chapter Chapter 6|15 pages
Ubiquitin-Mediated Regulation of Human Signaling Networks in Normal and Cancer Cells
chapter Chapter 8|17 pages
Network Model of Survival Signaling in T-Cell Large Granular Lymphocyte Leukemia
chapter Chapter 9|21 pages
Cancer Metabolic Networks: Metabolic Pathways Modeling and Metabolomics in Cancer Research
part II|90 pages
Cancer Biology: Basic Concepts and Cutting-Edge Topics
chapter Chapter 13|28 pages
Epithelial-to-Mesenchymal Transition (EMT)
part III|92 pages
Data Resources and Software Tools for Cancer Systems Biology