ABSTRACT

Demonstrating the relationship of the basic theory of solid-phase extraction (SPE) to chromatography, this comprehensive reference illustrates how SPE techniques significantly contribute to the preparation of samples for a wide variety of analytical techniques. It provides step-by-step details on the applications of SPE to environmental matrices, broad-spectrum drug screening, veterinary drug abuse, pharmaceutical drug development, biological samples, and high-throughput screening. Written by world-renowned experts in the field, the book contains helpful reference charts, tables of solvent properties, selectivities, molecular acid/base properties, and more.

Introduction to Solid-Phase Extraction. SPE Sorbents and Formats. The Sample Matrix and Its Influence on Method Development. Handling Large Volume Samples: Applications of SPE to Environmental Matrices. SPE Technology 150; Principles and Practical Consequences. Theory Meets Practice. Secondary Interactions and Mixed-mode Extraction. Solid-Phase Extraction for Broad-Spectrum Drug Screening in Toxicological Analysis. The Application of SPE to Veterinary Drug Abuse. Solid Phase Extraction of Biological Samples. Solid Phase Extraction Mediated by Covalent Bonding: Applications of Immobilized Phenylboronic Acid. Immuno-Affinity Extraction. Matrix Solid Phase Dispersion (MSPD). Automation of Solid Phase Extraction. Integration of SPE with the Analytical Technique, Part I - Liquid Chromatography. Integration of SPE with the Analytical Technique, Part II. Concluding Thoughts - New Directions for SPE. Appendices.