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http://dx.doi.org/10.1201/9780849387951
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Front MatterAbstract - Hi-Res PDF (240 KB) - PDF w/links (241 KB)
Chapter 1. Mechanisms of Antisense Drug Action, an IntroductionTimothy Vickers, Hongjiang Wu, Walt LimaAbstract - Hi-Res PDF (2637 KB) - PDF w/links (1383 KB)
Chapter 2. The RNase H MechanismHongjiang Wu, Walt LimaAbstract - Hi-Res PDF (1674 KB) - PDF w/links (996 KB)
Chapter 3. Small RNA Silencing PathwaysPhillip D. Zamore, Alla SigovaAbstract - Hi-Res PDF (226 KB) - PDF w/links (299 KB)
Chapter 4. Splice Switching Oligonucleotides as Potential TherapeuticsPeter Sazani, Maria A. Graziewicz, Ryszard KoleAbstract - Hi-Res PDF (651 KB) - PDF w/links (504 KB)
Chapter 5. Basic Principles of Antisense Drug DiscoveryAndrew T. Watt, Susan M. FreierAbstract - Hi-Res PDF (641 KB) - PDF w/links (524 KB)
Chapter 6. The Medicinal Chemistry of OligonucleotidesEric E. Swayze, Balkrishen BhatAbstract - Hi-Res PDF (581 KB) - PDF w/links (696 KB)
Chapter 7. Basic Principles of the Pharmacokinetics of Antisense Oligonucleotide DrugsRosie Z. Yu, Richard S. Geary, Arthur A. LevinAbstract - Hi-Res PDF (651 KB) - PDF w/links (673 KB)
Chapter 8. Routes and Formulations for Delivery of Antisense OligonucleotidesRichard S. Geary, Lloyd G. Tillman, Gregory E. HardeeAbstract - Hi-Res PDF (400 KB) - PDF w/links (417 KB)
Chapter 9. Liposomal Formulations for Nucleic Acid DeliveryIan MacLachlanAbstract - Hi-Res PDF (8516 KB) - PDF w/links (2109 KB)
Chapter 10. Pharmacological Properties of 2'-O-Methoxyethyl-Modified OligonucleotidesC. Frank BennettAbstract - Hi-Res PDF (3441 KB) - PDF w/links (1532 KB)
Chapter 11. Pharmacokinetic/Pharmacodynamic Properties ofPhosphorothioate 2'-O-(2-Methoxyethyl)-ModifiedAntisense Oligonucleotides in Animals and ManRosie Z. Yu, Richard S. Geary, Andrew Siwkowski, Arthur A. LevinAbstract - Hi-Res PDF (440 KB) - PDF w/links (466 KB)
Chapter 12. Toxicologic Properties of 2'-O-MethoxyethylChimeric Antisense Inhibitors in Animals and ManRobert A. Fey, Thomas A. Zanardi, Kimberly Kramer-Stickland, Scott P. Henry, Arthur A. Levin, Tae-Won KimAbstract - Hi-Res PDF (504 KB) - PDF w/links (545 KB)
Chapter 13. An Overview of the Clinical Safety Experience of First- and Second-Generation Antisense OligonucleotidesT. Jesse KwohAbstract - Hi-Res PDF (473 KB) - PDF w/links (500 KB)
Chapter 14. Manufacturing and Analytical Processes for 2'-O-(2-Methoxyethyl)-Modified OligonucleotidesDaniel C. Capaldi, Anthony N. ScozzariAbstract - Hi-Res PDF (950 KB) - PDF w/links (735 KB)
Chapter 15. Utilizing Chemistry to Harness RNA Interference Pathways for TherapeuticsMuthiah Manoharan, Kallanthottathil G. RajeevAbstract - Hi-Res PDF (1351 KB) - PDF w/links (1405 KB)
Chapter 16. Discovery and Development of RNAi TherapeuticsJohn M. Maraganore, Antonin R. de FougerollesAbstract - Hi-Res PDF (1629 KB) - PDF w/links (936 KB)
Chapter 17. Optimization of Second-Generation Antisense DrugsRosie Z. Yu, Brett P. Monia, Andrew Siwkowski, Walt LimaAbstract - Hi-Res PDF (654 KB) - PDF w/links (504 KB)
Chapter 18. Modulating Gene Function with Peptide Nucleic Acids (PNA)Peter E. NielsenAbstract - Hi-Res PDF (313 KB) - PDF w/links (356 KB)
Chapter 19. Locked Nucleic AcidTroels Koch, Henrik ØrumAbstract - Hi-Res PDF (664 KB) - PDF w/links (734 KB)
Chapter 20. MorpholinosPatrick L. IversenAbstract - Hi-Res PDF (299 KB) - PDF w/links (330 KB)
Chapter 21. Potential Therapeutic Applications of Antisense Oligonucleotides in OphthalmologyLisa R. Grillone, Scott P. HenryAbstract - Hi-Res PDF (306 KB) - PDF w/links (337 KB)
Chapter 22. Cardiovascular Therapeutic ApplicationsMark Wedel, Rosanne Crooke, Brenda BakerAbstract - Hi-Res PDF (2662 KB) - PDF w/links (1067 KB)
Chapter 23. Developing Antisense Drugs for Metabolic DiseasesSanjay BhanotAbstract - Hi-Res PDF (343 KB) - PDF w/links (344 KB)
Chapter 24. Inflammatory DiseasesJames G. Karras, Susan A. GregoryAbstract - Hi-Res PDF (1704 KB) - PDF w/links (571 KB)
Chapter 25. Antisense Oligonucleotides for the Treatment of CancerMartin E. Gleave, Boris A. HadaschikAbstract - Hi-Res PDF (2525 KB) - PDF w/links (514 KB)
Chapter 26. Targeting Neurological Disorders with Antisense OligonucleotidesRichard A. Smith, Timothy M. MillerAbstract - Hi-Res PDF (1514 KB) - PDF w/links (856 KB)
Chapter 27. Mechanisms and Therapeutic Applications of Immune Modulatory Oligodeoxynucleotide and Oligoribonucleotide Ligands for Toll-Like ReceptorsJörg Vollmer, Arthur M. KriegAbstract - Hi-Res PDF (335 KB) - PDF w/links (336 KB)
Chapter 28. Aptamer Opportunities and ChallengesCharles WilsonAbstract - Hi-Res PDF (1355 KB) - PDF w/links (1391 KB)
