CRCnetBASE - Alternative Toxicological Methods

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Alternative Toxicological Methods

Edited by Sidney A. Katz and Harry Salem

Informa Healthcare 2003

Print ISBN: 978-0-8493-1528-2

eBook ISBN: 978-0-203-00879-9

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http://dx.doi.org/10.1201/9780203008799

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Front Matter

Abstract - Hi-Res PDF (151 KB) - PDF w/links (151 KB)
Chapter 1. Historical Developments in the Humane Care and Use of Research Animals

Abstract - Hi-Res PDF (156 KB) - PDF w/links (173 KB)
Chapter 2. A History of Interagency Approaches to Alternatives and Establishment of the Interagency Regulatory Alternatives Group
Sidney Green

Abstract - Hi-Res PDF (89 KB) - PDF w/links (90 KB)
Chapter 3. The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM)
William S. Stokes

Abstract - Hi-Res PDF (356 KB) - PDF w/links (401 KB)
Chapter 4. Validation and Regulatory Acceptance of Alternative Test Methods
Michael Balls, Julia H. Fentem

Abstract - Hi-Res PDF (129 KB) - PDF w/links (135 KB)
Chapter 5. Integrated In Vitro Approaches for Assessing Systemic Toxicity
Bas Blaauboer, Anna Forsby

Abstract - Hi-Res PDF (204 KB) - PDF w/links (206 KB)
Chapter 6. Summary of the OECD’s New Guidance Document on the Recognition, Assessment, and Use of Clinical Signs as Humane Endpoints for Experimental Animals Used in Safety Evaluation
Errol Zeiger

Abstract - Hi-Res PDF (142 KB) - PDF w/links (150 KB)
Chapter 7. Pain and Distress Management in Animal Research and Testing
Martin L. Stephens, Kathleen M. Conlee, Andrew N. Rowan, Lori Donley, Francine Dolins, Adrienne M. Navarro

Abstract - Hi-Res PDF (213 KB) - PDF w/links (214 KB)
Chapter 8. Meeting Industry and Regulatory Needs for Alternative Test Methods to the Draize Rabbit Eye Irritation Test
Sherry L. Ward

Abstract - Hi-Res PDF (159 KB) - PDF w/links (164 KB)
Chapter 9. The Ocular Surface
Martin Reim

Abstract - Hi-Res PDF (405 KB) - PDF w/links (392 KB)
Chapter 10. Evaluation and Refinement of the Bovine Cornea Opacity and Permeability Assay
John L. Ubels, Phillip L. Casterton, James D. Paauw

Abstract - Hi-Res PDF (181 KB) - PDF w/links (181 KB)
Chapter 11. Corneal Organ Culture for Ocular Toxicity Test of Commercial Hair Care Products
Ke-Ping Xu, Fu-Shin X. Yu

Abstract - Hi-Res PDF (357 KB) - PDF w/links (194 KB)
Chapter 12. Human Corneal Equivalents for In Vitro Testing
May Griffith, Erik Suuronen

Abstract - Hi-Res PDF (135 KB) - PDF w/links (146 KB)
Chapter 13. The EpiOcular Prediction Model
Melissa M. Osborn, George L. DeGeorge, Patrick J. Hayden, Bridget A. Breyfogle, Kristen L. Bellavance, Daniel R. Cerven, Mitchell Klausner, Joseph Kubilus

Abstract - Hi-Res PDF (274 KB) - PDF w/links (272 KB)
Chapter 14. Three-Dimensional Construct of the Human Corneal Epithelium for In Vitro Toxicology
Martin Rosdy, Roger W. Beuerman, D. H. Nguyen, Bart DeWever

Abstract - Hi-Res PDF (735 KB) - PDF w/links (350 KB)
Chapter 15. The Human Corneal Epithelial HCE-T TEP Assay for Eye Irritation
Maximo Gacula, Sherry L. Ward, Henry F. Edelhauser

Abstract - Hi-Res PDF (1169 KB) - PDF w/links (401 KB)
Chapter 16. Alternative Methods for Dermal Toxicity Testing
Robert L. Bronaugh

Abstract - Hi-Res PDF (98 KB) - PDF w/links (101 KB)
Chapter 17. Allergic Contact Hypersensitivity
Denise M. Sailstad

Abstract - Hi-Res PDF (419 KB) - PDF w/links (287 KB)
Chapter 18. Validating In Vitro Dermal Absorption Studies
Michael Dellarco, Robert P. Zendzian

Abstract - Hi-Res PDF (362 KB) - PDF w/links (409 KB)
Chapter 19. A Molecular Diagnostic Approach to Irritant or Allergic Patch Testing Using the DermPatch
Nirmala Jayakumar, Vera B. Morhenn, Lawrence A. Rheins, Melissa M. Fitzgerald, Stacey B. Humphrey

Abstract - Hi-Res PDF (182 KB) - PDF w/links (224 KB)
Chapter 20. In Vitro Skin Equivalent Models for Toxicity Testing
Seyoum Ayehunie, G. Robert Jackson, Patrick J. Hayden, Mitchell Klausner, Sarah Kupfer-Lamore, Joseph Kubilus, Thomas J. Last

Abstract - Hi-Res PDF (496 KB) - PDF w/links (479 KB)
Chapter 21. Cellular Resistance of Tetrahymena to Sulfur Mustard
James E. Sistrunk, Peter L. Platteborze, William J. Smith

Abstract - Hi-Res PDF (150 KB) - PDF w/links (160 KB)
Chapter 22. Studies of Cellular Biochemical Changes Induced in Human Cells by Sulfur Mustard
Offie E. Clark, Maura E. Dejoseph, William J. Smith, Fred M. Cowan, Charisse Davenport, Clark L. Gross

Abstract - Hi-Res PDF (254 KB) - PDF w/links (209 KB)
Chapter 23. Human Keratinocyte Inflammatory Transcript Gene Activity Following Sulfur Mustard
James H. Clark, Douglas P. Avery, Kashif Ali, Hilma R. Benjamin, Claire F. Levine, John J. Schlager

Abstract - Hi-Res PDF (364 KB) - PDF w/links (203 KB)
Chapter 24. Evaluation of Cytotoxicity Assays of Human Epidermal Keratinocytes Exposed In Vitro to Sulfur Mustard
Susan A. Kelly, William J. Smith, Clark L. Gross, Juanita J. Guzman

Abstract - Hi-Res PDF (123 KB) - PDF w/links (134 KB)
Chapter 25. Comparison of Spectrophotometric and Fluorometric Assays of Proteolysis in Cultured Human Cells Exposed to Sulfur Mustard
Susan A. Kelly, William J. Smith, Marian R. Nelson, Clark L. Gross, Charlene M. Corun

Abstract - Hi-Res PDF (366 KB) - PDF w/links (236 KB)
Chapter 26. Effects of Low Dose Sulfur Mustard on Growth and DNA Damage in Human Cells in Culture
Janet E. Moser, Offie Clark, Bethany S. Toliver, Eric W. Nealley, William J. Smith, Clark L. Gross, Juanita J. Guzman

Abstract - Hi-Res PDF (176 KB) - PDF w/links (165 KB)
Chapter 27. Imaging Sulfur Mustard Lesions in Basal Cells and Human Epidermal Tissues by Confocal and Multiphoton Laser Scanning Microscopy
Robert J. Werrlein, Janna S. Madren-Whalley

Abstract - Hi-Res PDF (687 KB) - PDF w/links (433 KB)
Chapter 28. Suppression of Sulfur Mustard-Increased IL-8 in Human Keratinocyte Cell Cultures by Serine Protease Inhibitors
William J. Smith, Clarence A. Broomfield, Fred M. Cowan

Abstract - Hi-Res PDF (200 KB) - PDF w/links (208 KB)
Chapter 29. Development of Medical Countermeasures to Sulfur Mustard Vesication
William J. Smith, Michael C. Babin, Robyn C. Kiser, Robert P. Casillas

Abstract - Hi-Res PDF (183 KB) - PDF w/links (218 KB)
Chapter 30. Molecular Neurotoxicology of 6-Hydroxydopamine and Methamphetamine
Jean Lud Cadet

Abstract - Hi-Res PDF (233 KB) - PDF w/links (245 KB)
Chapter 31. A Microassay Method Using a Neuroblastoma Cell Line to Examine Neurotoxicity of Organophosphate Mixtures
Laurie E. Roszell, Benjamin C. Kramer, Glen J. Leach

Abstract - Hi-Res PDF (168 KB) - PDF w/links (185 KB)
Chapter 32. Development of Integrin Expression as a Molecular Biomarker for Early, Sensitive Detection of Neurotoxicity
Joyce E. Royland

Abstract - Hi-Res PDF (397 KB) - PDF w/links (378 KB)
Chapter 33. Two-Photon Fluorescence Microscopy
Peter T.C. So, Peter D. Kaplan, Christof Buehler, Lily Hsu, Chen-Yuan Dong, Thomas D. Hancewicz, Ki-Hean Kim

Abstract - Hi-Res PDF (323 KB) - PDF w/links (334 KB)
Chapter 34. The Application of Genomics and Proteomics to Toxicological Sciences
Stephan Chevalier, Ian Kimber, William D. Pennie

Abstract - Hi-Res PDF (178 KB) - PDF w/links (207 KB)
Chapter 35. Use of Transgenic Animals in Regulatory Carcinogenicity Evaluations
Abigail C. Jacobs, Frank D. Sistare

Abstract - Hi-Res PDF (262 KB) - PDF w/links (334 KB)
Chapter 36. Changes in Gene Expression after Exposure to Organophosphorus (OP) Agents
Akbar S. Khan, Jennifer W. Sekowski, Maha Khalil, Martin Nau, Kevin P. O’Connell, Maryanne Vahey, James J. Valdes, Mohyee E. Eldefrawi

Abstract - Hi-Res PDF (254 KB) - PDF w/links (257 KB)
Chapter 37. Archival Data in Toxicology
Millard M. Mershon

Abstract - Hi-Res PDF (325 KB) - PDF w/links (310 KB)
Chapter 38. Information Management at the Library of Congress
Roman B. Worobec

Abstract - Hi-Res PDF (270 KB) - PDF w/links (273 KB)
Chapter 39. World Wide Web Biomedical, Chemical, and lexicological Information Resources from the National Library of Medicine
Stephanie Publicker, James Knoben, George C. Fonger, Georgette Whiting, Philip Wexler

Abstract - Hi-Res PDF (261 KB) - PDF w/links (272 KB)
Chapter 40. In Silico Approaches for Physiologically Based Pharmacokinetic Modeling
Kannan Krishnan, Martin Béliveau

Abstract - Hi-Res PDF (984 KB) - PDF w/links (947 KB)
Chapter 41. In Silico Application of Quantum Chemical Methods for Relating Toxicity to Chemical Reactivity
William White

Abstract - Hi-Res PDF (125 KB) - PDF w/links (144 KB)
Chapter 42. In Silico Cardiac Toxicity
Csaba K. Zoltani, Steven I. Baskin

Abstract - Hi-Res PDF (323 KB) - PDF w/links (316 KB)
Chapter 43. Submillimeter-Wave Frequency Studies of the Vibrational Modes of Deoxyribonucleic Acid
M. Bykhovskaia, H. Salem, J. O. Jensen, D. L. Woolard, W. R. Loerop, B. L. Gelmont, A. C. Samuels, J. Hesler, T. R. Globus

Abstract - Hi-Res PDF (147 KB) - PDF w/links (165 KB)
Chapter 44. Trophoblast Toxicity Assay (TTA)
Harvey J. Kliman

Abstract - Hi-Res PDF (292 KB) - PDF w/links (293 KB)