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http://dx.doi.org/10.1201/9781420002546
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Front MatterAbstract - Hi-Res PDF (760 KB) - PDF w/links (333 KB)
Chapter 1. Basic Principles of Antisense TechnologyAbstract - Hi-Res PDF (1438 KB) - PDF w/links (444 KB)
Chapter 2. Medicinal Chemistry of Antisense OligonucleotidesP. Dan CookAbstract - Hi-Res PDF (1336 KB) - PDF w/links (386 KB)
Chapter 3. Analytical Methods for Antisense DrugsJanet M. Leeds, Lendell L. CumminsAbstract - Hi-Res PDF (1347 KB) - PDF w/links (366 KB)
Chapter 4. A Role for Antisense Technology in the Discovery of Highly Specific and Versatile Signal Transduction InhibitorsBrett P. Monia, Erich Koller, William A. GaardeAbstract - Hi-Res PDF (1371 KB) - PDF w/links (472 KB)
Chapter 5. Methods of Selecting Sites in RNA for Antisense TargetingSusan M. FreierAbstract - Hi-Res PDF (605 KB) - PDF w/links (187 KB)
Chapter 6. Pharmacokinetic Properties in AnimalsRichard S. Geary, Rosie Z. Yu, Janet M. Leeds, Michael V. Templin, Tanya A. Watanabe, Scott P. Henry, Arthur A. LevinAbstract - Hi-Res PDF (1572 KB) - PDF w/links (485 KB)
Chapter 7. Suborgan PharmacokineticsRosanne M. Crooke, Mark J. GrahamAbstract - Hi-Res PDF (1806 KB) - PDF w/links (547 KB)
Chapter 8. Pharmacokinetic Properties in HumansRosie Z. Yu, Steven L. Schoenfeld, Richard S. Geary, Tanya A. Watanabe, Arthur A. LevinAbstract - Hi-Res PDF (797 KB) - PDF w/links (233 KB)
Chapter 9. Toxicity of Antisense OligonucleotidesArthur A. Levin, Scott P. Henry, David Monteith, Michael V. TemplinAbstract - Hi-Res PDF (3927 KB) - PDF w/links (912 KB)
Chapter 10. Clinical Safety of Phosphorothioate OligodeoxynucleotidesF. Andrew Dorr, Josephine G. Glover, T. Jesse KwohAbstract - Hi-Res PDF (1080 KB) - PDF w/links (299 KB)
Chapter 11. General Pharmacology of Phosphorothioate OligodeoxynucleotidesC. Frank BennettAbstract - Hi-Res PDF (1533 KB) - PDF w/links (391 KB)
Chapter 12. Pharmacology of 2'-O-(2-Methoxy)ethyl- Modified Antisense OligonucleotidesNicholas M. Dean, Madeline Butler, Brett P. Monia, Muthiah ManoharanAbstract - Hi-Res PDF (1131 KB) - PDF w/links (345 KB)
Chapter 13. LNA (Locked Nucleic Acid)Jesper WengelAbstract - Hi-Res PDF (733 KB) - PDF w/links (249 KB)
Chapter 14. Antisense Properties of Peptide Nucleic Acid (PNA)Uffe Koppelhus, Peter E. NielsenAbstract - Hi-Res PDF (767 KB) - PDF w/links (251 KB)
Chapter 15. Phosphorodiamidate Morpholino OligomersPatrick IversenAbstract - Hi-Res PDF (675 KB) - PDF w/links (218 KB)
Chapter 16. Oligonucleotide Conjugates in Antisense TechnologyMuthiah ManoharanAbstract - Hi-Res PDF (3875 KB) - PDF w/links (1026 KB)
Chapter 17. Immune Stimulation by OligonucleotidesArthur M. KriegAbstract - Hi-Res PDF (2434 KB) - PDF w/links (584 KB)
Chapter 18. Pre-mRNA Splicing as a Target for Antisense OligonucleotidesRyszard Kole, Danielle MercatanteAbstract - Hi-Res PDF (1184 KB) - PDF w/links (332 KB)
Chapter 19. Application of Antisense Oligonucleotides to the Study of CNS Protein FunctionSiew Peng HoAbstract - Hi-Res PDF (1566 KB) - PDF w/links (379 KB)
Chapter 20. Antisense Approach to Isoform-Specific Blockade of AcetylcholinesteraseHermona E. Soreq, Schlomo SeidmanAbstract - Hi-Res PDF (1092 KB) - PDF w/links (346 KB)
Chapter 21. Serine/Threonine Protein PhosphatasesRichard E. HonkanenAbstract - Hi-Res PDF (1353 KB) - PDF w/links (439 KB)
Chapter 22. Pharmacological Activities of Antisense DrugsJames G. Karras, Kathleen J. Myers, Brenda F. BakerAbstract - Hi-Res PDF (3691 KB) - PDF w/links (904 KB)
Chapter 23. Respirable Antisense Oligonucleotides (RASONs)Jonathan W. NyceAbstract - Hi-Res PDF (302 KB) - PDF w/links (111 KB)
Chapter 24. Combined Antisense Therapy and Chemotherapy in Animal ModelsDan mercolaAbstract - Hi-Res PDF (1169 KB) - PDF w/links (325 KB)
Chapter 25. Antisense Oligodesoxynucleotide Strategies in Renal and Cardiovascular DiseaseHermann Haller, Christian Maasch, Duska Dragun, Maren Wellner, Friedrich C. LuftAbstract - Hi-Res PDF (1101 KB) - PDF w/links (263 KB)
Chapter 26. The Development of Antisense Oligonucleotides as AntiviralsLisa R. GrilloneAbstract - Hi-Res PDF (728 KB) - PDF w/links (216 KB)
Chapter 27. Clinical Activities in Patients with Solid Tumors or LymphomaJon T. HolmlundAbstract - Hi-Res PDF (1073 KB) - PDF w/links (330 KB)
Chapter 28. Nucleic Acid Therapeutics for the Treatment of Human Leukemialan M. GewirtzAbstract - Hi-Res PDF (550 KB) - PDF w/links (228 KB)
Chapter 29. ISIS 2302, an Antisense Inhibitor of Intercellular Adhesion Molecule 1 (ICAM-1)William R. Shanahan JrAbstract - Hi-Res PDF (1214 KB) - PDF w/links (327 KB)
Chapter 30. New Routes and Novel Formulations for Delivery of Antisense OligonucleotidesGregory E. Hardee, Susan P. Weinbach, Lloyd G. TillmanAbstract - Hi-Res PDF (1736 KB) - PDF w/links (509 KB)
Chapter 31. DNA-Binding MoleculesRoland W. Bürli, Heinz E. MoserAbstract - Hi-Res PDF (1352 KB) - PDF w/links (432 KB)
Chapter 32. Targeted Genome Modification via Triple Helix FormationMargaret A. Macris, eter M. GlazerAbstract - Hi-Res PDF (1380 KB) - PDF w/links (429 KB)
Chapter 33. Intracellular Ribozyme ApplicationsJohn J. RossiAbstract - Hi-Res PDF (923 KB) - PDF w/links (298 KB)
