ABSTRACT

Given the increased attention of clinicians, researchers, and the pharmaceutical industry to the management and treatment of dementia not only in the elderly but also in increasingly younger populations, the demands for effective evidence-based pharmaceutical control of dementia and quantitative assessment of outcomes have increased. From the first steps in the early 1960s to the controversial landmark paper of Summers and colleagues to the most recent trials, it is clear both that much progress has been made and that much remains to be done. This book is written to take stock of what is now usefully known and to speculate on directions for the future.

chapter 1|9 pages

Introduction

chapter 3|11 pages

Treatment Hypotheses

chapter 5|20 pages

The Use of Qualitative Research

chapter 6|10 pages

Inclusion and Exclusion Criteria

chapter 7|9 pages

Global Assessment Measures

chapter 8|28 pages

Cognitive Outcomes

chapter 9|6 pages

Functional Outcomes

chapter 10|11 pages

Behavioural Outcomes

chapter 11|10 pages

Quality of Life Outcomes

chapter 12|12 pages

Caregiver Burden Outcomes

chapter 13|11 pages

Structural Neuroimaging Outcomes

chapter 17|9 pages

Clinical Trials for Memantine

chapter 20|8 pages

Pharmacoeconomic Outcomes

chapter 21|7 pages

Executive Dysfunction in Dementia

chapter 24|11 pages

Conclusion