ABSTRACT
SOLID LIPID NANOPARTICLES Solid lipid nanoparticles (SLNs) are reported to be an alternative system to emulsions, liposomes, or polymeric nanoparticles (1-3). Different approaches can be employed to prepare SLNs, including (i) high-pressure homogenization at high or low temperatures, (ii) warm microemulsions, (iii) solvent emulsificationevaporation-diffusion, (iv) high-speed stirring, and/or (v) sonication (4). This chapter considers their in vivo application, discussing, in particular, SLNs obtained from warm microemulsions.
