ABSTRACT
In any drug treatment, the overall goal of drug delivery is to achieve and maintain therapeutic concentrations of the drug at its site of action for sufficient time to produce a beneficial effect. One of the simplest approaches to sustained drug delivery is the formulation of a drug in a viscous gel, cream, or ointment. Many microencapsulated drug delivery systems, such as nanoparticles and micro-spheres, often composed of biocompatible, bioerodible polymers, have been developed. Liposomes have been investigated as an alternate delivery system; most works to date have used liposomes as drug reservoir systems rather than as means to achieve cellular or intracellular targeting. Proliferative vitreoretinopathy is characterized by the proliferation of cells, thought to be mainly retinal pigment epithelial cells, macrophages, and fibroblasts on the retinal surface, undersurface, and within the vitreous. Systemically administered acetazolamide can enhance subretinal fluid absorption across the retinal pigment epithelium and has been investigated as a means to treat chronic macular edema.
