ABSTRACT

There is a huge amount of literature on statistical models for the prediction of survival after diagnosis of a wide range of diseases like cancer, cardiovascular disease, and chronic kidney disease. Current practice is to use prediction models based on the Cox proportional hazards model and to present those as static models for remaining lifetime a

part I|2 pages

Prognostic models for survival data using (clinical) infor- mation available at baseline, based on the Cox model

chapter 1|12 pages

The special nature of survival data

chapter 2|20 pages

Cox regression model

chapter 4|14 pages

Calibration and revision of Cox models

part II|2 pages

Prognostic models for survival data using (clinical) in- formation available at baseline, when the proportional haz- ards assumption of the Cox model is violated

chapter 6|16 pages

Non-proportional hazards models

chapter 7|18 pages

Dealing with non-proportional hazards

part III|2 pages

Dynamic prognostic models for survival data using time-dependent information

chapter 8|14 pages

Dynamic predictions using biomarkers

chapter 9|18 pages

Dynamic prediction in multi-state models

chapter 10|16 pages

Dynamic prediction in chronic disease

part IV|2 pages

Dynamic prognostic models for survival data using ge- nomic data

chapter 11|14 pages

Penalized Cox models

chapter 12|8 pages

Dynamic prediction based on genomic data

chapter V|24 pages

Appendices