ABSTRACT

Today much of what we know about the neurochemistry and function of the central nervous system (CNS) has been aided by the use of natural products.1 Many of the receptors within the CNS were discovered by studying their interactions with natural products; for example, research on opium alkaloids from Papaver somniferum L. (Papaveraceae) guided researchers to the discovery of the opioid receptors and has helped to elucidate the mechanism of antinociception mediated by these receptors.1-3 In this case, ethnopharmacological knowledge has aided the identication and study of

CONTENTS

10.1 Introduction .......................................................................................................................... 247 10.2 Ion Channels .........................................................................................................................248