ABSTRACT
Acknowledgment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 312
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 314
This chapter describes multi-modal optical imaging techniques combining OCT with FLOT for
depth-resolved imaging of tissuemorphology andmolecular function. OCT provides high-resolution,
cross-sectional imaging of tissue microstructure. Depth-resolved FLOT provides highly-sensitive
molecular information through fluorescence contrast agents. Multi-modal OCT/FLOT provides
more comprehensive information for biomedical applications. This chapter will describe the theo-
retical modeling, instrumentation, as well as biomedical applications of this new multi-modal imag-
ing modality.
