ABSTRACT
Over the past decades, triumphant sounds of fanfare many a time heralded the remark able discoveries in different areas of chemistry, biology, and medicine. These great victories overshadowed signicant breakthroughs in our understanding of the chemical mechanisms involved in liquid-phase, free radical-driven oxidation reactions. Unexpectedly, these advancements in chemistry had a huge impact on several biomedical disciplines and denoted the emergence of a new eld of knowledge and practice-free radical biology and medicine. The major methodological approaches based on the employment of electron paramagnetic resonance (EPR) spectroscopy and different versions of chemiluminescence techniques, including detection of low-level chemiluminescence from animal and plant tissues in vivo (reviewed in Vladimirov and Proskurnina 2009) further stimulated the development of free radical concepts of biomedicine. The discoveries of oxygen radicals in living systems and their regulating enzymes in cells and tissues also gave a strong boost to free radical enthusiasm. Finally, introduction and development of a concept of lowmolecular-weight sacricial antioxidants-small water-and lipid-soluble molecules capable of scavenging reactive radicals and slowing down the overall oxidation
1.1 Oxygenated Lipids in Apoptosis .......................................................................4 1.2 Oxidized Lipids as Damage-Associated Molecular Patterns ...........................8 Acknowledgments ......................................................................................................9 References ..................................................................................................................9
